Compare Sildenafil, Tadalafil, and Vardenafil

There are a lot of drugs for Erectile Dysfunction that one can buy in our online pharmacy. The active ingredients for the most popular ED drugs are Sildenafil, Tadalafil, and Vardenafil. Sildenafil Citrate is the main ingredient of Viagra, Viagra soft, Kamagra, Kamagra soft, Kamagra oral jelly, Aurogra, Eriacta, Suhagra, and Silagra. Tadalafil is the main ingredient of Cialis, Cialis Soft, Apcalis oral jelly, Tadacip, and Erectalis. Finally, Vardenafil is the main ingredient of Levitra.

While there are a lot of similarities between them given that they all have the same effect, it's the small differences that set them apart. Let us find out the similarities and differences between these three ingredients and determine what drug best suits you.

The differences between these three drugs lie in their chemical structure and efficacy.

Comparison Chart of the 3 PDE-5 Inhibitors:

Onset of Results
1 hour 30 min before 15 min before
30 min – 1 hour
Acts in 15 min
15 min – 1 hour
sexual activity
of Effects
4 hours
Lasts 36 hours
6 hours
You should take Sildenafil orally 30 minutes to 1 hour before sexual activity. Effectiveness lasts approximately 4 hours for one dose.

Tadalafil is recommended to take orally 15 minutes before sexual activity. Its effectiveness may last as long as 36 hours for one dose.

Vardenafil should be taken orally approximately 1 hour before sexual activity. It starts to act in 15 to 60 minutes and the effect usually lasts 5 to 6 hours.


Sildenafil is the most prescribed of the three drugs, partly because of its safety profile that has spanned for more than ten years. Sildenafil has been verified to work safely in men with erectile dysfunction - including men of all ages, men who have varying difficulty in achieving erection, and men with different health issues. Thus, we can say that Sildenafil works for most men with little side effects.

Sildenafil comes in 25, 50, and 100 milligram tablets. They should be taken one hour before sex. The regular dosage is 50 milligrams, although the doctor will have to verify the right dosage for his patient. The effect of the drug shows 30 to 60 minutes after drinking it and it lasts up to four hours. Sildenafil has also shown a positive effect on blood pressure and heart rate, which are the main conditions associated with erectile dysfunction.

Sildenafil can change one's color perception. Thus, you are advised not to drive a car when under medication. If you need to drive or need to eat a full meal, it is better to use Tadalafil.


The main advantage of Tadalafil over Sildenafil is that it is not dependent on alcohol intake or meals. Patients taking Tadalafil should take them 16 minutes prior to sex. Tadalafil requires 20 mg dosage, although the recommended starting dose is only 10 mg.

Tadalafil is the only drug between the three that can be administered as a daily medication. The effect of Tadalafil can take up to an impressive 17.5 to 36 hours, which is far longer than the life of Sildenafil. However, Tadalafil can cause myalgia. If you are worried about heart complications, you can use Vardenafil.


Vardenafil has a softer effect on the individual's cardiovascular system. This drug comes in 5, 10, and 20 milligram tablets and should be taken twenty five to sixty minutes prior to intercourse. The effect of the drug can last for 5-6 hours. However, this drug should not be taken more than once per day.

Erectile Dysfunction

Sildenafil, Tadalafil, and Vardenafil treat Erectile Dysfunction (the inability of a man to achieve and maintain erections in order to perform sexually). There are many reasons for Erectile Dysfunction (cardiovascular complications, diabetes, hormonal imbalance, psychological problems, neurological problems, etc.), but the prime factor why this happens is because blood does not rush to the penis at the right amount.

The first option to treat erectile dysfunction is a set dosage of phosphodiesterase type 5 (PDE 5) drugs, the class where Sildenafil, Tadalafil, and Vardenafil belong. Upon dosage, the penis muscles smoothens which increases the blood flow within the penis and induce erection.

All these drugs enhance the natural mechanisms that cause erection. These medicines provide an added value to a man's lifestyle since they make sexual contact very possible. They are presented in tablet form for convenient dosage. These drugs are taken orally and are designed so that the body can quickly absorb them for faster effect.

However, men should note that each medicine has different level of efficacy and that erection is not possible without sexual stimulation. Consult your doctor before you choose the medicine that is right for you.